Immigrating to America is the biggest fresh start I am aware of for my Ormiston ancestors. Originating from the area of Carnwath in South Lanarkshire. They came from Scotland aboard the Brig Prince Kutusoff, here is the passenger list, and landed in Philadelphia on May 12, 1828. On www.familysearch.org, I found images of the index cards for David age 28, Jane age 28, James age 4 years 6 months, John age 1 year 1 month, and Wm Ormiston age 2 years 4 months. Source: http://www.genuki.org.uk/big/sct/LKS/Carnwath/ I wasn't able to find an image of the ship for that time period. If you find one, post a link in the comments.
They didn't stay long and moved on to Washington County, Ohio. They had many more fresh starts as the Ormiston descendents moved from Ohio into Missouri following the Civil War. Later, at the turn of the 20th century, they moved on into Kansas and some into Colorado.